lossofimprinting

由 TM Holm 著作 · 2005 · 被引用 331 次 — Loss of imprinting (LOI), commonly observed in human tumors, refers to loss of monoallelic gene regulation normally conferred by parent-of-origin-specific ...

Loss of imprinting (i.e., the loss of normal allele-specific gene expression) can also result in cancer when an imprinted, normally silent allele that ...

由 S Bar 著作 · 2017 · 被引用 78 次 — present a large-scale analysis of loss of imprinting (LOI) in human pluripotent stem cells (hPSCs). They demonstrate differences in LOI.

由 P Jelinic 著作 · 2007 · 被引用 295 次 — Imprinting is defined as the parental allele-specific expression of a very limited set of genes (about 50-80). This regulation depends upon an epigenetic ...

2006年12月18日 — Thus LOI occurs at high frequency in a large variety of human tumours. It is presently considered to be the most common alteration in cancer 49.

This study has two major results. First, we report that hypomethylation, rather than hypermethylation, is linked to LOI of IGF2 in human CRC based on two lines ...

由 C Vincenz 著作 · 2020 · 被引用 16 次 — The mechanisms that lead to LOI of imprinted genes are likely to involve loss of the imprint, not acquisition of new repressive marks on the ...

由 KS Park 著作 · 2017 · 被引用 29 次 — Loss of imprinting at the Igf2/H19 locus disrupts in vitro differentiation of primary myoblasts. The H19ΔICR mutation is a deletion that removes ...

由 GV Fitzpatrick 著作 · 2002 · 被引用 547 次 — Offspring inheriting a deletion of KvDMR1 from their fathers were 20–25% smaller by weight than their wildtype littermates. This growth deficiency was first ...